The best way to reach Mendoza is via a connecting flight from either Buenos Aires, Argentina (EZE) or Santiago, Chile (SCL). From Buenos Aires, it is 2 hours by plane or 13 hours by bus to Mendoza. From Santiago, it is 50 minutes by plane or 6 hours by bus. If you come from Santiago, you will have the opportunity to survey the Andes as you cross over into Argentina.